Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD

Laval University

Status: Unknown

Conditions: Pulmonary Disease, Chronic Obstructive

Treatments: Other: Fatiguing exercise

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT01909544

MX-20665

Details and patient eligibility

About

The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.

Enrollment: 20 estimated patients

Sex: All

Ages: 50 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
• Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
• Smoking history > 15 pack-years

Exclusion criteria

• Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg)
• Recent exacerbation (< 3 months)
• Recent cancer (< 3 years)
• Diabetes
• Myopathy, neuromuscular or articular disease
• Unstable cardiac disease
• Absolute contraindications to exercise testing
• Regular physical activity or exercise training program in the last 2 months
• Physical activity score > 9 in the Voorips questionnaire
• Thigh skinfold thickness > 15 mm
• BMI > 30

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Oxygen

Experimental group

Treatment:

Other: Fatiguing exercise

Room air

Sham Comparator group

Treatment:

Other: Fatiguing exercise