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Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD

L

Laval University

Status

Unknown

Conditions

Pulmonary Disease, Chronic Obstructive

Treatments

Other: Fatiguing exercise

Study type

Interventional

Funder types

Other
Industry

Identifiers

NCT01909544
MX-20665

Details and patient eligibility

About

The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.

Enrollment

20 estimated patients

Sex

All

Ages

50 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • COPD (FEV1/FVC < 0.70 and FEV1 < 0.80 predicted
  • Healthy subjects: no evidence of airways obstruction (FEV1/FVC > 0.70 and FEV1 > 0.80 predicted)
  • Smoking history > 15 pack-years

Exclusion criteria

  • Chronic hypoxemia and/or hypercapnia (PaO2 < 60 mmHg or SpO2 < 88% at rest and/or PaCO2 > 45 mmHg)
  • Recent exacerbation (< 3 months)
  • Recent cancer (< 3 years)
  • Diabetes
  • Myopathy, neuromuscular or articular disease
  • Unstable cardiac disease
  • Absolute contraindications to exercise testing
  • Regular physical activity or exercise training program in the last 2 months
  • Physical activity score > 9 in the Voorips questionnaire
  • Thigh skinfold thickness > 15 mm
  • BMI > 30

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

20 participants in 2 patient groups

Oxygen
Experimental group
Treatment:
Other: Fatiguing exercise
Room air
Sham Comparator group
Treatment:
Other: Fatiguing exercise

Trial contacts and locations

1

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Central trial contact

Fernanda Ribeiro, PhD candidate

Data sourced from clinicaltrials.gov

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