Muscle Relaxation for Short Procedures

Helio's Health

Status: Completed

Conditions: Intubating Conditions; Patient Satisfaction; Sore Throat; Postoperative Myalgia; Fasciculations

Treatments: Drug: Rocuronium; Drug: Rocuronium/Sugammadex; Drug: Succinylcholine

Study type: Interventional

Funder types: Industry

Identifiers

NCT01902641

2011_333N-MA (Registry Identifier)

HSK001

Details and patient eligibility

About

Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), as well as patient satisfaction for these two muscle relaxants.

Enrollment: 105 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age > 18 yr
• scheduled for elective rigid bronchoscopy

Exclusion criteria

• known neuromuscular disease
• significant hepatic or renal dysfunction
• family history of malignant hyperthermia
• known allergy to one of the drugs used in this protocol
• pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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105 participants in 3 patient groups

Succinylcholine

Active Comparator group

Description:

Patient received succinylcholine as a muscle relaxant(0.5 mg /kg)for induction of anaesthesia for rigid bronchoscopy.

Treatment:

Drug: Succinylcholine

Rocuronium/Sugammadex

Active Comparator group

Description:

Patient received rocuronium (0.25 mg/ kg) as muscle relaxant for induction of anaesthesia for rigid bronchoscopy, at the end of procedure rocuronium was reversed with sugammadex (0.5mg/kg.)

Treatment:

Drug: Rocuronium/Sugammadex

Rocuronium

Active Comparator group

Description:

Patients received rocuronium (0.25 mg /kg)as muscle relaxant for induction of anaesthesia for rigid bronchoscopy.

Treatment:

Drug: Rocuronium