Muscle Soreness and Stiffness in Patients With Chronic or Frequent Episodic Tension Type Headache.

D

Danish Headache Center

Status

Completed

Conditions

Tension-type Headache

Treatments

Drug: Amitriptyline

Study type

Interventional

Funder types

Other

Identifiers

NCT02746250
H-16000619

Details and patient eligibility

About

The aim is to investigate muscle soreness and stiffness in patients with Chronic or Frequent Episodic Tension Type Headache before and after treatment with amitriptyline - and to compare the results with healthy individuals.

Full description

The muscle stiffness is measured with ultrasonic shear wave elastography in m. masseter, m. sternocleidomastoid and m. Trapezius. The muscle soreness is measured by palpation of the muscles aided by a so called palpometer.

Enrollment

46 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Chronic Tension type headache or frequent episodic tension type headache with at least ten episodes or more per month throughout three months or more.
  • Pericranial muscle tenderness

Exclusion criteria

  • Other primary headache disorder (with the exception of episodic migraine.)
  • Pregnancy or ongoing breastfeeding
  • Heart disease that contradicts treatment with amitriptyline
  • Drug or substance abuse

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

46 participants in 2 patient groups

Tension type headache
Active Comparator group
Description:
The investigator measures the muscle soreness and muscle stiffness before the patients starts their prescribed treatment with amitriptyline - and again after they have reached their optimal dosage of amitriptyline.
Treatment:
Drug: Amitriptyline
Healthy controls
No Intervention group
Description:
The investigator measures the muscle soreness and muscle stiffness once.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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