Muscle Tenderness and Hardness in Migraine Patients

D

Danish Headache Center

Status

Completed

Conditions

Muscle Tenderness
Migraine Disorders
Nervous System Diseases
Headache, Migraine
Headache Disorders, Primary

Study type

Observational

Funder types

Other

Identifiers

NCT03626805
001

Details and patient eligibility

About

The aim of the study is to examine symptomatology, quantitative sensory test (QST) parameters, muscle tenderness and muscle hardness in migraine patients interictally and compare with healthy controls

Full description

Migraine patients exhibit different symptomatology and responses to treatment. For example do many migraine patients have neck symptoms, despite they apparently do not have any neck disorders.Furthermore the response to treatment differs between patients. Differences in symptomatology, QST parameters and muscle stiffness can be used to subdivide and phenotype migraine patients. The investigators are examining migraine patients with: A semistructured interview, Quantitative sensory testing (cold pain threshold, heat pain threshold and Pin Prick), Muscle tenderness (total tenderness score, local tenderness score and stimulus response curve), and muscle hardness with ultrasound elastography. All tests are performed the same day

Enrollment

146 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Migraine Patients from the Danish Headache Centre. Migraine classified using the International Classification of Headache Disorders (ICHD3) criteria.

Exclusion criteria

  • Pregnant or lactating women
  • Musculoskeletal injuries in the neck or shoulder
  • Other primary headache disorders than migraine or Tension Type Headache
  • On the time of examination: Migraine free for at least 48 hours
  • On the time of examination: haven't trained the upper body for at least 48 hours
  • On the time of examination: haven't used painkillers for at least 48 hours

Healthy controls:

Exclusion Criteria:

  • Pregnant or lactating women
  • Musculoskeletal injuries in the neck or shoulder
  • Migraine disorders
  • 1. degree relatives with migraine disorders
  • Over 1 day of tension type headache a month.
  • On the time of examination: haven't trained the upper body for at least 48 hours
  • On the time of examination: haven't used painkillers for at least 48 hours

Trial design

146 participants in 2 patient groups

Migraine patients
Description:
Migraine patients attending the Danish Headache Centre
Healthy Controls
Description:
Age and sex matched

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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