Muscle Typology and Strength Training Adaptations (MT-ST)

University Ghent

Status: Completed

Conditions: Training Frequency; Muscle Fiber Type; Exercise

Treatments: Other: Muscle typology + exercise training; Other: Muscle typology + training frequency

Study type: Interventional

Funder types: Other

Identifiers

NCT05108181

BC-10253

Details and patient eligibility

About

The overall aim of this project is to investigate if the responsiveness to chronic resistance training is dependent on the muscle typology. In a second aim we will investigate the most optimal training frequency for slow-twitchers and fast-twitchers. For the latter we hypothesize that slow-twitchers might cope better with higher frequencies and higher volumes compared to fast-twitchers.

Male and female adult participants (18-45y) will be recruited. The subjects' muscle typology will be non-invasively estimated in the leg muscles by measurement of muscle carnosine using H-MRS. In total 21 subjects (11 slow and 10 fast subjects) will participate. Subjects will be assigned to a whole-body resistance training exercise protocol of 9 weeks in wich arm A and leg A will train 3 times per week and arm B and leg B will train 2 times per week. Before and following the training period, subjects will be subjected to different measurements (fitness level, muscle volume, strength tests, blood sampling, muscle biopsies).

Enrollment: 60 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Fast or slow muscle typology
• 18 - 45 years old
• no strength training experience

Exclusion criteria

• Vegan/vegeterian diet
• Supplement intake
• chronic diseases
• Hypertension,
• Smoking
• Medication use
• Coagulation disorder, infectious diseases

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Slow muscle typology group

Active Comparator group

Description:

The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.

Treatment:

Other: Muscle typology + training frequency

Other: Muscle typology + exercise training

Fast muscle typology group

Active Comparator group

Description:

The participants receive the same exercise training intervention, but they are divided in two groups: a slow typology group and a fast typology group based on their inherent physiological characteristics: their muscle fiber type.

Treatment:

Other: Muscle typology + training frequency

Other: Muscle typology + exercise training