Muscle Weakness and Post-traumatic Knee OA

University of Florida

Status: Completed

Conditions: Meniscectomy

Treatments: Behavioral: Quadriceps intensive strengthening; Behavioral: Standard rehabilitation

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT01879852

00060374

K01HD052713 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This is a single-center, randomized, single-blind (evaluator) study. Enrolled patients had a traumatic meniscal tear and underwent meniscectomy. The study included 6 weeks (12 visits) of standard or quadriceps intensive rehabilitation. The objective of the study was to determine the effect of quadriceps intensive rehabilitation on knee function and articular cartilage.

Enrollment: 29 patients

Sex: All

Ages: 15 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. traumatic onset meniscal tear (i.e. specific mechanism of injury)
2. meniscectomy surgery performed within 12 months of index injury
3. meniscal tear confirmed at the time of surgery
4. subject anticipates living in close proximity to Gainesville for one year following surgery.

Exclusion criteria

1. bilateral injury
2. concomitant ligamentous injury
3. previous knee injury
4. articular cartilage defect > Grade II on Outerbridge scale
5. patellofemoral joint pain > 3/10 with activity
6. lower limb alignment > 5 degrees of valgus or varus
7. contraindication to an MR examination including: a pacemaker, metal implants which are not MR compatible, pregnancy and severe claustrophobia.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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29 participants in 2 patient groups

Standard Rehabilitation

Active Comparator group

Description:

Standard meniscectomy rehabilitation including knee range of motion and strengthening exercises.

Treatment:

Behavioral: Standard rehabilitation

Standard Rehabilitation + Quadriceps intensive strengthening

Experimental group

Description:

The intervention includes high-intensity neuromuscular electrical stimulation and eccentric exercises for the quadriceps muscle in addition to the standard rehabilitation protocol.

Treatment:

Behavioral: Quadriceps intensive strengthening

Behavioral: Standard rehabilitation