Musculoskeletal Ultrasound in Asymptomatic Hyperuricemia

Washington D.C. Veterans Affairs Medical Center

Status: Unknown

Conditions: Hyperuricemia

Treatments: Other: Uric acid level

Study type: Observational

Funder types: Other; Other U.S. Federal agency; Industry

Identifiers

NCT02502565

MIRB #01580

Details and patient eligibility

About

An observational study to evaluate the prevalence of US changes of gout in the joints and tendons of patients with different degrees of asymptomatic hyperuricemia. The investigators' findings may support the extension of the spectrum of urate disease, and define a subset of patients that may benefit from early urate-lowering therapy.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients must have at least one serum uric acid level l ≥ 7.0 mg/dL within the last two years without a clinical diagnosis of gout per American College of Rheumatology criteria30 (appendix A).
2. Patients, of matched gender and age, with normal uric acid levels will serve as controls.

Exclusion criteria

1. Patients who meet or have met the ACR criteria for Gout, unable to read English, and/or have terminal illness will not be eligible to participate in the study.
2. Patients with a diagnosis of skin psoriasis31, rheumatoid arthritis, or spondyloarthropathies will not be eligible to participate.
3. Patients who are on urate-lowering therapy.
4. Patients with 1 or 2 total knee replacements.

Trial design

150 participants in 1 patient group

Uric Acid Level

Treatment:

Other: Uric acid level