Music After Stroke To Enhance Rehabilitation (MASTER)

Pace University

Status: Unknown

Conditions: Expressive Aphasia; Stroke, Acute; Depressive Disorder; Movement, Abnormal

Treatments: Device: ipod only with usual care; Device: Ipod with music; Device: ipod with books to listen

Study type: Interventional

Funder types: Other

Identifiers

NCT04441515

MASTER1

Details and patient eligibility

About

Music that is familiar and preferred by patients has been shown to heighten neuroplasticity and can mitigate these disabilities. Therefore, this study seeks to explore the effect of providing patient preferred music to patients in the very early post stroke period (within 24 hours of a left cerebral artery stroke [LMCA]event) as a complementary modality to usual stroke care.

Full description

Aim I. The primary aim of MASTER is to identify whether a potential relationship exists between an intervention of participant preferred music, when initiated within the first 24 hours following a left middle cerebral artery stroke, and a reduction in the following disabilities: Expressive aphasia, right hand functional deficit and post stroke depression. This aim will serve to address the first research hypothesis and address the relationship between These disabilities are well known sequalae among patients diagnosed with the most common form of stroke, a LMCA stroke. Participant preferred music within the first 24 hours following a LMCA stroke and a reduction in: Expressive aphasia, right hand functional deficit and post stroke depression, as these disabilities are well known sequalae among LMCA stroke patients.

Aim II. The second aim of MASTER is to identify if a relationship exists between an intervention of audible books, when initiated within the first 24 hours following a LMCA stroke, and a reduction in the following disabilities: Expressive aphasia, right hand functional deficit and post stroke depression.

Sufficient evidence exists to suggest that although listening to books stimulates cognitive function, the effect of melody and participant engagement in music is far superior to listening to words alone as the inherent rhythmicity of patient-favored music has been shown to strengthen synchronous neuronal connectivity, by modulating dopamine and inducing fine grained neuroanatomical changes in a recovering brain.

Enrollment: 12 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of LMCA stroke within prior 24 hours
• Not identified as critically ill
• Glascow Coma Scale > 8 at time of consent
• Resident of a home with a land line or cell phone
• Able to speak in English or Spanish prior to stroke event
• Presence of expressive aphasia at time of enrollment.

Exclusion criteria

• Stroke diagnosis other than LMCA territory stroke
• Unable to provide consent by patient or legally accountable person acting on behalf of the patient (healthcare proxy, healthcare power of attorney), Patient/ representative
• Does not speak English or Spanish prior to stroke event
• Have a diagnosis of end stage cancer, or other medical conditions that dramatically increase a risk of mortality within one year
• Any pre-existing communication disorder (including dementia)
• Patients that are deemed critically ill will not be included

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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12 participants in 3 patient groups, including a placebo group

Music

Experimental group

Description:

music supplied by ipod

Treatment:

Device: Ipod with music

oral books

Active Comparator group

Description:

Listening to books on ipod

Treatment:

Device: ipod with books to listen

usual care

Placebo Comparator group

Description:

Usual care

Treatment:

Device: ipod only with usual care