Musical Attention Control and Executive Function Training for Adults with MDD

Unity Health Toronto

Status: Completed

Conditions: Major Depressive Disorder; Cognitive Dysfunction; Suicide

Treatments: Other: Music-based cognitive training

Study type: Interventional

Funder types: Other

Identifiers

NCT05694156

MBCT-01

Details and patient eligibility

About

The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques. The music-based cognitive training sessions will address areas of attention and executive function, which appear to progress over time and worsen as an individual experiences more episodes of depression. The aim of this pilot is to test 8-weeks of music-based cognitive training to improve cognitive function among adults with major depressive disorder.

Full description

Major Depressive Disorder (MDD) is a lifelong condition and is the leading cause of disability in the world. MDD is a multifaceted mood disorder and due to its complex nature, this mental health diagnosis affects emotional, behavioural, and cognitive processing. Cognitive dysfunction appears to progress over time and worsens as the individual experiences more episodes of depression. Because of this, it is critical to continue to investigate and formulate effective treatment that can target and improve not only depressive symptoms, but also address overall cognitive function. Thus, the investigators propose implementing music-based cognitive training derived from Neurologic Music Therapy (NMT) techniques to address cognitive dysfunction experienced by adults diagnosed with MDD. Music-based interventions, specifically from the NMT approach have been shown to physically change the human brain when working on cognition in areas of attention and executive function, however little is known of these applications with adults with MDD. The aim of this pilot is to test 8-weeks of music-based cognitive training to improve cognitive function among adults with MDD.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of MDD meeting the Diagnostic and Statistical Manual Diploma in Social Medicine (DSM-V) criteria
• Experiencing suicidal ideation in the past week (Beck Scale for Suicide Ideation >10)
• Have received more than 12 sessions of psychotherapy
• Stable medication use > 4 weeks
• Ability to undergo music-based cognitive training sessions in English
• Capable of giving informed consent

Exclusion criteria

• The presence of cognitive impairment that would limit consent or understanding of neurologic music therapy
• The presence of active psychosis
• The presence of mood and suicidal symptom severity requiring immediate treatment
• Hearing impairment
• Participation in music therapy 6 months prior to study
• Private music lessons for a period of 1 year prior to study
• Unwilling or unable to provide informed consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Music-based cognitive training

Experimental group

Description:

Music-based cognitive training sessions are derived from two Neurologic Music Therapy techniques: Musical Attention Control Training (MACT) and Musical Executive Function Training (MEFT). MACT exercises will focus on sustained and selective attention to emphasise flexibility and adaptability of the auditory attention system. MEFT exercises will provide opportunity for decision making, problem solving, reasoning, comprehending, organising, initiating, inhibiting, evaluating, analysing, and creating.

Treatment:

Other: Music-based cognitive training