Mutation of the LEPR Gene at Reunion Island: Involvement in Pediatric Obesity (GREOL)

Centre Hospitalier Universitaire de la Réunion

Status: Unknown

Conditions: Obesity, Childhood

Study type: Observational

Funder types: Other

Identifiers

NCT04329260

2019/CHU/04

Details and patient eligibility

About

The objective of this study is to estimate the proportion of the recurrent deletion Δ6-8 of the LEPR gene in the homozygous and heterozygous state in pediatric cases with severe and early ( before the age of 6) obesity (BMI ≥ IOTF-30) on Reunion Island.

Full description

The study of the deletion Δ6-8 of the LEPR gene starts with a saliva sample using a swab in children aged between 3 to 18 years old.

The DNA from this sample will then be analyzed by the PCR technique. If the deletion of the LEPR gene is confirmed in the patient, his adult family members will also be screened using the same procedure.

Enrollment: 250 estimated patients

Sex: All

Ages: 3 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient with early severe and non syndromic obesity (BMI> IOTC-30) (before 6 years old)
• adult family members with deletion of LEPR gene
• informed consent form signed by participants or parents
• affiliation to social security scheme

Exclusion criteria

• patient with syndromic obesity
• patient Under guardianship or Under judicial protection

Trial design

250 participants in 2 patient groups

Pediatric population

Description:

Children between 3 to 18 years old with severe (BMI\> IOTF-30) and early (before the age of 6) obesity. A Saliva sample for screening of the deletion Δ6-8 of LEPR gene will be performed for each child.

Adult member family

Description:

The screening of the same deletion according the same procedure will be proposed to the adult family member if the child presents the deletion Δ6-8 of LEPR gene.