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Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia (MUTA-GR)

C

CHU de Reims

Status

Completed

Conditions

General Glucocorticoid Resistance

Treatments

Genetic: blood collection for mutation characterization

Study type

Interventional

Funder types

Other

Identifiers

NCT02810496
PN11010

Details and patient eligibility

About

As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of Cushing's disease. In all these patients GR gene will be studied, mutations will be detected and described, functional disturbance will be tested. Usual polymorphisms will be described. Correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of GR mutations will be searched.

Enrollment

150 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients more than 18 years of age
  • patients with bilateral adrenal masses

Exclusion criteria

  • Refusing to participate in the study
  • Protected by law
  • Have obvious signs of Cushing's syndrome
  • No progressive neoplastic disease

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

150 participants in 1 patient group

patient
Experimental group
Treatment:
Genetic: blood collection for mutation characterization

Trial contacts and locations

1

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Central trial contact

Brigitte DELEMER

Data sourced from clinicaltrials.gov

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