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Cyclosporin decreases proteinuria and improve renal function in patients with idiopathic membranous nephropathy, but has a risk of side effects such as nephrotoxicity. The investigators plan to the study to evaluate whether mycophenolate mofetil (MMF) could be a reasonable alternative with fewer side effect.
Full description
Idiopathic membranous nephropathy is most common cause of glomerulonephritis in adults. Persistent high grade proteinuria or progressively decrease of renal function is a risk factor for end stage renal disease in idiopathic membranous nephropathy. It has been reported that cyclosporin in patients with idiopathic membranous nephropathy decreases proteinuria and improve renal function. Mycophenolate mofetil is a recently developed immunosuppressive agent with fewer side effect than cyclosporin. In this study patients with high risk group of progressive idiopathic membranous nephropathy will be treated with mycophenolate mofetil and low dose prednisone. The outcome will be compared to controls treated with cyclosporin and low dose prednisone.
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Inclusion criteria
Patients with idiopathic membranous nephropathy
The duration of disease is less than twelve months
Patients with persistent proteinuria more than 8 grams per day
Patients who provided informed consent
The cases that satisfy more than three of following items even if proteinuria is less than 8 grams per day:
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
62 participants in 2 patient groups
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Central trial contact
Hee-Yeon Jung, MD
Data sourced from clinicaltrials.gov
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