Mycoprotein and Pea Protein Blend and Muscle Protein Synthetic Response (BPM)

University of Exeter

Status: Completed

Conditions: Muscle Protein Synthesis

Treatments: Dietary Supplement: Bolus ingestion of protein

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04894747

200325_B_04UOE

Details and patient eligibility

About

Dietary protein is vital for the preservation of health and optimal adaptation to training. Plant proteins are considered inferior to animal proteins with respect to their ability to stimulate an acute muscle building response and therefore support long-term muscle reconditioning. Pea protein is a highly commercially available plant proteins source (available as supplements, food ingredients etc.), yet there is no research investigating its ability to stimulate a muscle building response. The investigators aim to assess the effect of consuming pea protein on muscle protein synthesis rates and compare these results to mycoprotein, a source known to elicit a robust anabolic response.

Pea protein is lower in some of the essential amino acids, namely methionine, which could mean it is less effective compared with mycoprotein which has a more complete amino acid profile. So in addition to comparing pea with mycoprotein, the investigators also want to compare to a blend of pea and mycoprotein to see if replenishing the amino acid content in pea 'rescues' the anabolic response.

Enrollment: 33 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 18 and 30
• Resistance trained

Exclusion criteria

• Any metabolic impairment
• Smoking
• Use of over the counter pharmaceuticals (excluding oral contraceptives and contraceptive devices).
• A personal family history of epilepsy, seizures or schizophrenia.
• Allergic to Quorn/mycoprotein/edible fungi/environmental mould products.
• Any motor disorder.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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33 participants in 3 patient groups

Mycoprotein

Experimental group

Description:

Bolus ingestion of mycoprotein providing 25g of protein.

Treatment:

Dietary Supplement: Bolus ingestion of protein

Pea protein

Experimental group

Description:

Bolus ingestion of pea protein providing 25g of protein.

Treatment:

Dietary Supplement: Bolus ingestion of protein

Mycoprotein/pea protein dry blend

Experimental group

Description:

Bolus ingestion of mycoprotein/pea protein dry blend providing 25g of protein.

Treatment:

Dietary Supplement: Bolus ingestion of protein