ClinicalTrials.Veeva

Menu

Myeloid Derived Suppressor Cells Control by Signal Regulatory Protein-alpha: Investigation in Hepatocellular Carcinoma (MDScan)

N

Nantes University Hospital (NUH)

Status

Completed

Conditions

Hepatocellular Carcinoma

Treatments

Procedure: Collection of human samples

Study type

Observational

Funder types

Other

Identifiers

NCT02868255
RC16_0156

Details and patient eligibility

About

project is to study and develop anti-Signal Regulatory Protein α (SIRPα) antibodies (Ab) as a new immunotherapy strategy in cancer.

Samples harvested from hepatocellular carcinoma (HCC) and ovarian cancer patients will be used in evaluation of the SIRP-CD47 expression and of the effect of the anti-human Signal Regulatory Protein (hSIRP) Ab on various cellular types from patients and healthy volunteers.

Enrollment

30 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • adult
  • HCC patients (all BCLC stages accepted)
  • patient consent for the use of their biological samples

Exclusion criteria

  • patient with other cancers
  • hepatitis C or B positive
  • HCC treatment by chemo-embolization under 3 months
  • under Sorafenib treatment within the month prior to collection
  • underage or under guardianship patients

Trial design

30 participants in 3 patient groups

Ascites
Description:
30 inflammatory ascites of HCC patients (Collection of human samples ) Ascites will be selected only from HCC patients with an elevated protein level (ie inflammatory ascites) Puncture of ascites will be collected by paracentesis on HCC or ovarian cancer patients during their routine care These biological samples are affiliated with the biobank "hépato-gastroentérologie du CHU de Nantes" (declared under the reference DC-2011-1399).
Treatment:
Procedure: Collection of human samples
Resections
Description:
30 HCC resections (Collection of human samples ) Fragment of resected HCC will be obtained after surgery and histological analysis will be performed by the anatomo-pathology service These biological samples are affiliated with the biobank "hépato-gastroentérologie du CHU de Nantes" (declared under the reference DC-2011-1399).
Treatment:
Procedure: Collection of human samples
blood samples
Description:
blood samples (Collection of human samples )will be collected prospectively for complementary functional analysis of peripheral These biological samples are affiliated with the biocollection "hépato-gastroentérologie du CHU de Nantes" (declared under the reference DC-2011-1399).
Treatment:
Procedure: Collection of human samples

Trial contacts and locations

0

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems