Myo-inositol/D-chiro-inositol Ratio in Follicular Fluid

Lo.Li.Pharma

Status: Completed

Conditions: Women Infertility

Treatments: Other: Dosage of D-chiro-inositol; Other: Dosage of myo-inositol

Study type: Observational

Funder types: Industry

Identifiers

NCT03055442

MI/DCI_FF

Details and patient eligibility

About

Considering the importance assumed by follicular microenvironment for a proper oocyte development, this study is a prospective observational clinical trial which aims to evaluate whether the embryo blastocyst quality may be affected by different Myo-inositol (MI) and D-chiro-inositol (DCI) levels in the follicular fluid (FF) of the aspired oocytes. The study includes egg donors and egg receiving couples participating in the oocyte donation program. MI/DCI is calculated in FF and related with blastocyst grade.

Enrollment: 34 patients

Sex: Female

Ages: 18 to 28 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• clear follicular aspirate obtained during oocyte retrieval;
• each specimen of follicular fluid containing only one oocyte.

Exclusion criteria

• hyperglycaemic women;
• PCOS women also if euglycaemic;
• diabetic subjects having low concentrations of detectable MI in association with an anomalous MI transport.

Trial design

34 participants in 1 patient group

Follicular Fluids

Description:

Follicular fluids obtained by 8 oocyte donors

Treatment:

Other: Dosage of D-chiro-inositol

Other: Dosage of myo-inositol