myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies (MYOARRAY)

University Hospital, Rouen

Status: Completed

Conditions: Dermatomyositis; Polymyositis

Treatments: Other: transcriptome analysis; Other: T cell repertoire analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT00213629

2003/094/HP

Details and patient eligibility

About

The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care.

Objective 1 : to develop and evaluate the diagnostic value of a dedicated DNA-array (myoARRAY) for adult-onset muscular diseases with focus on inflammatory myopathies.

Objective 2 : to evaluate the diagnostic value of T cell repertoire (TcLand) analysis to distinguish different forms of inflammatory myopathies.

Enrollment: 100 patients

Sex: All

Ages: 18 to 76 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• indication of muscle biopsy for diagnostic purpose
• written informed consent

Exclusion criteria

• vasculitis
• coagulation disorder, impossibility to perform muscle biopsy

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

no arm

Other group

Description:

no arm

Treatment:

Other: T cell repertoire analysis

Other: transcriptome analysis