Myocardial Biopsy in Congenital Cardiac Surgery

Assiut University

Status: Unknown

Conditions: Myocardial Protection

Treatments: Procedure: myocardial biopsy

Study type: Interventional

Funder types: Other

Identifiers

NCT03595111

IRB00008715964

Details and patient eligibility

About

Despite major advances in the technical aspects of surgical repair of congenital heart diseases, perioperative myocardial damage with low cardiac output remains the most common cause of morbidity and death after repair of congenital heart lesions.

Full description

Myocardial sample was obtained from the endocardial surface of the right ventricle and placed in formalin until examination under light microscopy for detection of myocyte cellular edema as a marker of ischemic changes.

Enrollment: 60 estimated patients

Sex: All

Ages: 2 to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Scheduled cardiac surgery requiring cardioplegic arrest with expected cross clamp time>45 minutes.

Hemodynamic stability.

Exclusion criteria

Previous cardiac surgery. Urgent or emergent cases. Any known allergies to components of either cardioplegia solutions.

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Myocardial biopsy

Experimental group

Description:

The specimens were classified into three categories: normal, focal hydropic change and diffuse hydropic change.

Treatment:

Procedure: myocardial biopsy