Myocardial Blood Flow by 15O Water PET

University of Edinburgh

Status: Completed

Conditions: Coronary Heart Disease

Treatments: Other: Oxygen 15 labelled water positron emission tomography; Other: Computed tomography myocardial perfusion imaging

Study type: Observational

Funder types: Other

Identifiers

NCT01805193

12/SS/0078

Details and patient eligibility

About

Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease. In this study the investigators plan to investigate a special scan called a PET/CT (Positron emission tomography/computed tomography) and a new type of CT (Computed tomography) scan to tell us about the flow of blood to the heart muscle.

Full description

Participants will undergo PET/CT with oxygen-15 labelled water and computed tomography myocardial perfusion imaging.

Enrollment: 22 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• suspected coronary artery disease

Exclusion criteria

• inability or unwillingness to undergo CT or PET imaging
• renal failure (serum creatinine >200 um/L or eGFR <30 ml/min)
• hepatic failure
• allergy to iodinated contrast
• pregnancy
• contraindication to adenosine
• inability to give informed consent
• atrial fibrillation with a fast ventricular rate (>70 beats per minute)

Trial design

22 participants in 1 patient group

Suspected coronary heart disease

Treatment:

Other: Oxygen 15 labelled water positron emission tomography

Other: Computed tomography myocardial perfusion imaging