Myocardial Fibrosis and Inflammation in Liver Cirrhosis

University Hospital Bonn (UKB)

Status: Completed

Conditions: Portal Hypertension; Cirrhosis, Liver; Cardiomyopathies

Treatments: Diagnostic Test: Magnetic resonance imaging; Procedure: Transjugular intrahepatic portosystemic shunt implantation

Study type: Observational

Funder types: Other

Identifiers

NCT05047029

282/18_1

Details and patient eligibility

About

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).

Enrollment: 13 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• liver cirrhosis with evaluation of TIPS implantation
• patients who are 18 years of age or older

Exclusion criteria

• underlying cardiac disease, e.g. known myocardial infarction, previous myocarditis, congenital heart disease, cardiomyopathies of other causes known underlying disease witt potential cardiac involvement, e.g. storage disease (e.g. hemochromatosis, Fabry disease), inflammatory (e.g. sarcoidosis), endocrinological (e.g. diabetes mellitus, hyper-/hypothyroidism), autoimmune (e.g. systemic lupus erythematosus, dermatomyositis, rheumatoid arthritis), therapeutic (chemotherapy).
• patients with contraindication for contrast-enhanced MRI
• pregnant and breastfeeding women

Trial design

13 participants in 1 patient group

Patients with cirrhosis

Description:

Patients with cirrhosis and transjugular intrahepatic portosystemic shunt implantation.

Treatment:

Procedure: Transjugular intrahepatic portosystemic shunt implantation

Diagnostic Test: Magnetic resonance imaging