Myocardial Fibrosis, Function and Aging (MARVEL)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Healthy

Treatments: Biological: Blood sampling; Device: MRI; Biological: Skin auto-fluorescence

Study type: Interventional

Funder types: Other

Identifiers

NCT03064503

69HCL15_0744

Details and patient eligibility

About

In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• physical activity ≤ 3 x(30') per week
• no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (<140 or <90 mmHg) and no anti-hypertensive or cardiovascular-related medications
• no familial history of early myocardial ischemia
• body mass index (BMI) <30kg/m2
• normal routine lipid blood analysis
• glycemia <1.26g/l
• normal electrocardiogram (ECG)

Exclusion criteria

• arrhythmia
• hepatic insufficiency
• pregnancy
• claustrophobia
• MRI contrast allergy,
• general contraindications to MRI such as pacemaker, etc.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Healthy volunteers

Experimental group

Description:

Sedentary healthy subjects will be recruited in this study. MRI, skin auto-fluorescence measures and blood sampling will be performed

Treatment:

Biological: Blood sampling

Biological: Skin auto-fluorescence

Device: MRI