Myocardial Flow Reserve and 99mTc-DTPA Cardiac Dynamic SPECT (Flow-Heart)

Caen University Hospital

Status

Unknown

Conditions

Coronary Artery Disease

Treatments

Other: Cardiac SPECT

Study type

Interventional

Funder types

Other

Identifiers

NCT02844686

16-004

2016-000119-34 (EudraCT Number)

Details and patient eligibility

About

New CZT-based SPECT cameras are potentially capable of dynamic 3-D acquisition. Preliminary results suggested that dynamic acquisitions could allow the assessment of myocardial flow reserve using 99mTc-labelled perfusion tracers. The Flow-Heart study will assess the feasibility of myocardial flow reserve measurement by means of 99mTc-DTPA dynamic cardiac SPECT in 20 patients.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age over 18 years
Patient clinically stable with known or suspected coronary disease
Patient referred to Caen University Hospital for a myocardial perfusion SPECT
Patient who accept to undergo subsequent additional cardiac dynamic SPECT using 99mTc-DTPA at rest and during pharmacological stress
Informed consent dated and signed
Affiliation to a social security system

Exclusion criteria

Contraindication to dipyridamole (asthma, chronic obstructive pulmonary disease , pulmonary hypertension)
History of poor tolerance of dipyridamole injection
Cardiac arrhythmia (atrial fibrillation or frequent premature ventricular complex)
Left bundle branch block, cardiac pacemaker, or implantable automatic defibrillator
Recent history of myocardial infarction or unstable angina
Pregnancy or lactating women
Known obstructive renal or urinary disease
Age under 18 years or guardianship
Patient with an acute coronary syndrome or a coronary revascularization occurring between the conventional perfusion SPECT and the subsequent 99mTc-DTPA dynamic SPECT