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Myocardial Flow Reserve and 99mTc-DTPA Cardiac Dynamic SPECT (Flow-Heart)

C

Caen University Hospital

Status

Unknown

Conditions

Coronary Artery Disease

Treatments

Other: Cardiac SPECT

Study type

Interventional

Funder types

Other

Identifiers

NCT02844686
16-004
2016-000119-34 (EudraCT Number)

Details and patient eligibility

About

New CZT-based SPECT cameras are potentially capable of dynamic 3-D acquisition. Preliminary results suggested that dynamic acquisitions could allow the assessment of myocardial flow reserve using 99mTc-labelled perfusion tracers. The Flow-Heart study will assess the feasibility of myocardial flow reserve measurement by means of 99mTc-DTPA dynamic cardiac SPECT in 20 patients.

Enrollment

20 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age over 18 years
  • Patient clinically stable with known or suspected coronary disease
  • Patient referred to Caen University Hospital for a myocardial perfusion SPECT
  • Patient who accept to undergo subsequent additional cardiac dynamic SPECT using 99mTc-DTPA at rest and during pharmacological stress
  • Informed consent dated and signed
  • Affiliation to a social security system

Exclusion criteria

  • Contraindication to dipyridamole (asthma, chronic obstructive pulmonary disease , pulmonary hypertension)
  • History of poor tolerance of dipyridamole injection
  • Cardiac arrhythmia (atrial fibrillation or frequent premature ventricular complex)
  • Left bundle branch block, cardiac pacemaker, or implantable automatic defibrillator
  • Recent history of myocardial infarction or unstable angina
  • Pregnancy or lactating women
  • Known obstructive renal or urinary disease
  • Age under 18 years or guardianship
  • Patient with an acute coronary syndrome or a coronary revascularization occurring between the conventional perfusion SPECT and the subsequent 99mTc-DTPA dynamic SPECT

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

Cardiac Dynamic SPECT
Experimental group
Treatment:
Other: Cardiac SPECT

Trial contacts and locations

0

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Central trial contact

Denis Agostini, MD, PhD; Alain Manrique, MD, PhD

Data sourced from clinicaltrials.gov

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