Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work

Sun Yat-sen University

Status

Active, not recruiting

Conditions

Coronary Artery Disease

Noninvasive Myocardial Work

Treatments

Diagnostic Test: Transthoracic echocardiography

Study type

Observational

Funder types

Other

Identifiers

NCT05874752

SYSKY-2022-029-01

Details and patient eligibility

About

Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) myocardial function in symptomatic patients with coronary artery disease using the promising method.

Methods: Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography. Images were stored and imported into the software for further offline analysis of PSL-based MW. MW analysis were carried out on each patient for global and regional myocardial function assessment.

Enrollment

130 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Patients who were hospitalized for coronary angiography with angina or equivalent symptoms.

Exclusion Criteria: Acute coronary syndrome, left main stem coronary disease, left ventricular ejection fraction (LVEF) below 55%, observed resting regional wall motion abnormalities (RWMAs), non-sinus rhythm, intraventricular block, previous cardiac surgery, severe valvular heart disease, hypertrophic cardiomyopathy, myocarditis, pericardial diseases, pulmonary hypertension, and poor image quality.