Myocardial Infarction and Periodontitis: Periodontal Health Intervention.

Tongji University

Status: Enrolling

Conditions: Acute Myocardial Infarction (AMI); Periodontal Disease

Treatments: Procedure: Periodontal surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT06745141

CCS-MIP-PHI

Details and patient eligibility

About

The aim of this study is to establish a shared database of acute myocardial infarction patients with periodontitis, to clarify the clinical benefits of periodontitis intervention on acute myocardial infarction patients through simulated RCT study, and to establish a high-level database of acute myocardial infarction patients with periodontitis, so as to promote the application of oral health intervention in clinical practice.

Enrollment: 100 estimated patients

Sex: All

Ages: 30+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1)Patients diagnosed with ST-segment elevation myocardial infarction (STEMI). 2)Patients with severe periodontal disease, defined as:

  • 5 teeth with clinical attachment loss (CAL) ≥ 4 mm.

    • Subgingival probing depth (PD) ≥ 6 mm. ③≥ 8 teeth with gingival bleeding on probing (BOP). 3）Age ≥30 years. 4）Written informed consent provided.

Exclusion criteria

• 1. under 30 years old; 2) HIV positive, chronic inflammation, tumor disease, drug dependence, use of anticonvulsants, use of immunosuppressive agents, pregnancy, and lactation; 3) significant tooth loss (number of remaining teeth < 8); 4) long hospital stay (>10 days), new myocardial infarction before randomization, and stent thrombosis; 5) Refusal to sign informed consent.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Periodontal Health Intervention Group

Experimental group

Description:

Participants in this arm will receive comprehensive periodontal health interventions, including: 1. Full periodontal evaluation using dental mirrors and probes (assessing visible plaque, probing depth, bleeding on probing, and attachment loss). 2. Supragingival scaling, root planing, and professional plaque removal. 3. Temporary restoration of carious lesions and extraction of root remnants, as needed. 4. Personalized oral hygiene instruction, including the use of multi-tufted brushes, toothpaste, floss, and interdental brushes.

Treatment:

Procedure: Periodontal surgery

Standard Care Group

No Intervention group

Description:

Participants in this arm will receive standard care without specific periodontal interventions. This includes routine medical management for myocardial infarction, as per standard clinical guidelines, without structured periodontal treatment.