Myocardial Infarction Prediction

Shiraz University of Medical Sciences

Status: Completed

Conditions: Artificial Neural Network; Myocardial Infarction

Treatments: Other: ANN prediction of myocardial infarction

Study type: Interventional

Funder types: Other

Identifiers

NCT01870258

90-8037

Details and patient eligibility

About

prediction of MI in patients with chest pain and nondiagnostic ECG was done in 2 weeks

Full description

Myocardial infarction remains one the leading causes of mortality and morbidity and involves a high cost of care. Early prediction can be helpful in preventing the development of myocardial infarction with appropriate diagnosis and treatment. Artificial neural networks have opened new horizons in learning about the natural history of diseases and predicting cardiac disease.

Methods: A total of 935 cardiac patients with chest pain and nondiagnostic electrocardiogram (ECG) were enrolled and followed for 2 weeks in two groups based on the appearance of myocardial infarction. Two types of data were used for all patients: nominal (clinical data) and quantitative (ECG findings). Two different artificial neural networks - radial basis function (RBF) and multi-layer perceptron (MLP) - were used.

Enrollment: 1,100 patients

Sex: All

Ages: 40 to 72 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient with chest pain refered to ER with nondiagnostic ECG

Exclusion criteria

• 1. Absence of a history of myocardial infarction
• 2. Absence of bundle branch block, Wolf-Parkinson-White abnormality, ventricular hypertrophy or previous ECG signs of myocardial infarction,
• 3. Absence of a history of percutaneous coronary surgery or coronary artery bypass grafting,
• 4. Absence of ECG abnormalities attributable to drugs such as digoxin or tricyclic antidepressants.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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1,100 participants in 2 patient groups, including a placebo group

those without MI in 2 weeks

Placebo Comparator group

Description:

patient without MI in 2 weeks

Treatment:

Other: ANN prediction of myocardial infarction

patient with MI

Active Comparator group

Description:

group with MI in 2 weeks

Treatment:

Other: ANN prediction of myocardial infarction