Myocardial Mechanics in Athlete's Heart

Central Hospital, Nancy, France

Status: Completed

Conditions: Athlete Heart

Treatments: Other: Cardiopulmonary exercise testing; Other: Echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT05543525

2022PI064

Details and patient eligibility

About

Echocardiographic assessment of the endurance athletes' heart remains challenging due to a phenotypic overlap between reactive physiological adaptation and pathological remodelling. The lower range of normal values of lLeft ventricle systolic ejection fraction (LVEF) and global longitudinal strain (GLS) in athletes makes it difficult to differentiate changes related to adaptive remodelling or indicative of early cardiomyopathy.

This study aims to improve the assessment of athletes' hearts by identifying echocardiographic phenotypes, using a speckle tracking including temporal deformation pattern and layer-specific approach, and to define predictive factors of subtle LV systolic dysfunction and of mechanical LV abnormalities.

Full description

Healthy male athletes belonging to local clubs, who underwent a pre-participation medical evaluation at the University Hospital of Nancy between 2013 and 2020, will be screened. Clinical, echocardiographic and cardiopulmonary exercise testing data will be compared to a group of healthy men from the STANISLAS cohort. Subtle LV dysfunction will be defined by a GLS <17.5%.

Enrollment: 191 patients

Sex: Male

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020

Exclusion criteria

• female athletes,
• athletes followed for cardiomyopathy
• athletes who did not have transthoracic echocardiography (TTE) performed.

Trial design

191 participants in 2 patient groups

Male Athletes

Description:

Athletes who underwent a pre-participation medical evaluation in the Nancy University Hospital between January 1st, 2013, and January 1st, 2020.

Treatment:

Other: Echocardiography

Other: Cardiopulmonary exercise testing

Control Group

Description:

A subgroup of 161 participants in a population-based cohort (STANISLAS Cohort) restricted by age and sex to create a control group in the current analysis.

Treatment:

Other: Echocardiography

Other: Cardiopulmonary exercise testing