Myocardial Minimal Damage After Rapid Ventricular Pacing (MyDate)

German Heart Center Munich

Status

Completed

Conditions

Antitachycardia Pacing

Treatments

Device: Implantable Cardioverter Defibrillator

Study type

Interventional

Funder types

Other

Identifiers

NCT02362802

GER-EP-015

Details and patient eligibility

About

This study aims to investigate the impact of antitachycardia pacing ( ATP) on the myocardial tissue with respect to its potential micro damage measured by several myocardial markers, especially by high-sensitive TroponinT.

Enrollment

149 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients for de-novo implantation of a transvenous ICD (single chamber, dual chamber or cardiac resynchronization tehrapy) with left pectoral device position and planned apical location of the right ventricular defibrillation electrode.

Exclusion criteria

Resuscitation, cardiac surgical procedure, acute coronary syndrome, acute myocardial infarction, coronary revascularisation, cardioversion or ablation during the past 4 weeks, if baseline high-sensitive Troponin T is elevated
Known stenosis of coronary vessels with indication for coronary intervention or operative revascularisation
Intracardiac thrombus or general contraindication against ventricular burst stimulation or intraoperative ICD-testing
Atypical lead implantation with indication for defibrillation threshold testing by induction of ventricular fibrillation
Right sided implantation of ICD
Planned electrical cardioversion
Lead explantation or -extraction during procedure
Redo procedure (except of additional implantation of a right ventricular ICD lead)
Present temporary pacemaker electrode
ASA >= IV or NYHA IV
Cardiogenic shock
Pulmonary embolism, cerebrovascular insult or dialysis in the past 4 weeks
Lack of consent of patient
Minority of patient