Myocardial Performance at Rest and During Exercise in Heart Failure With Preserved Ejection Fraction (X-HF-SPECKLE)

Mayo Clinic

Status: Terminated

Conditions: Heart Failure

Treatments: Other: Cardiopulmonary exercise test; Other: Cardiac rehabilitation; Other: Myocardial deformation imaging

Study type: Observational

Funder types: Other

Identifiers

NCT01747785

12-005553

Details and patient eligibility

About

This study is being done to study how well the heart contracts and relaxes during exercise. In addition to traditional measures of heart function, we will use a new computer program that may improve understanding of why people feel shortness of breath or fatigue.

Full description

Heart failure with preserved ejection fraction is not well understood, although account for nearly half of all heart failure cases. This study aims to collect data about systolic (contracting portion of a heart beat) and diastolic (relaxing portion of a heart beat) dysfunction at rest and during exercise. Participants with normal cardiac function will serve as a control group and compared to participants who are at risk of heart failure.

Enrollment: 21 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18 years of age or older,
• able to exercise on a bicycle

Exclusion criteria

• heart arrhythmias,
• severe chronic obstructive pulmonary disease,
• congenital heart abnormalities,
• infiltrative or hypertrophic cardiomyopathy.

Trial design

21 participants in 2 patient groups

Healthy controls

Description:

Individuals without history of cardiovascular disease and at least 18 years of age will take a baseline (at rest) cardiopulmonary exercise test (CPX) and have a cardiac echocardiogram to measure myocardial deformation. CPX and echocardiograms will be repeated during exercise sessions at 3 visits over a 12 week period.

Treatment:

Other: Cardiopulmonary exercise test

Other: Myocardial deformation imaging

Patients at risk of heart failure

Description:

Individuals at risk of heart failure and a preserved ejection fraction of at least 50% will take a baseline (at rest) cardiopulmonary exercise test (CPX) and have a baseline cardiac echocardiogram to measure myocardial deformation. CPX and echocardiograms will be repeated during exercise sessions at 6 visits over a 12 week period. A cardiac rehabilitation exercise program will also occur over 12 weeks.

Treatment:

Other: Cardiopulmonary exercise test

Other: Cardiac rehabilitation

Other: Myocardial deformation imaging