Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery (TRIMRIPC)

Norwegian University of Science and Technology

Status: Completed

Conditions: Myocardial Injury

Treatments: Behavioral: Exercise training; Procedure: remote ischemic preconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT01308138

TRIMRIPC

Details and patient eligibility

About

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Enrollment: 60 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing coronary heart surgery and heart transplantation

Exclusion criteria

• myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

ExerciseTr

Experimental group

Treatment:

Behavioral: Exercise training

Remote ischemic preconditioning group

Experimental group

Treatment:

Procedure: remote ischemic preconditioning

Control patient group

No Intervention group