Myocardial Stress Perfusion Imaging With Dual Source CT

Mass General Brigham

Status: Completed

Conditions: Coronary Artery Disease

Treatments: Other: Adenosine Stress Dual-source CTP

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00853671

DSCTSTRESS

Details and patient eligibility

About

The investigators propose a novel technique using dual source multidetector computed tomography (DSCT) where information on both coronary anatomy and myocardial perfusion is obtained in a single scan. The investigators hypothesize that a coronary CTA protocol can be devised to obtain resting myocardial perfusion, myocardial perfusion after stress, and coronary anatomy. Hence, one diagnostic test will be able to detect the presence of coronary plaque as well as assess the functional significance of a stenosis.

Enrollment: 50 patients

Sex: All

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• A prior adenosine or exercise stress SPECT exam with high likelihood of being referred to the cardiac catheterization laboratory for invasive angiogram
• Age > 40 years old
• Able to comprehend and sign the consent form.

Exclusion criteria

• Acute coronary syndromes (unstable angina, non-ST elevation myocardial infarction, ST elevation myocardial infarction)
• Unstable clinical conditions (i.e. hemodynamic instability, arrhythmias)
• Premenopausal women who have a positive pregnancy test.
• Serum Creatinine level ≥1.5 mg/dl as an indicator of renal insufficiency.
• Known allergy to iodinated contrast agents
• Atrial fibrillation
• Asthma
• Critical aortic stenosis
• Systolic blood pressure < 90 mmHg
• Advanced heart block

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Adenosine Stress Dual-source CTP

Experimental group

Description:

A multiphase adenosine Stress Dual-source stress perfusion computed tomography imaging test, as described above, will be performed in all patients.

Treatment:

Other: Adenosine Stress Dual-source CTP