Myocardialbridge Bypass Graft Surgery Efficacy Verification

Xi'an International Medical Center Hospital

Status: Enrolling

Conditions: Myocardial Ischemia; Bypass Graft Occlusion; Bypass Graft Stenosis; Myocardial Bridging; Myocardial Bridge of Coronary Artery; Pectoris, Stable Angina; Myocardial Bridge; Bypass Graft Thrombosis; Myocardial Infarction; Sudden Cardiac Death

Treatments: Procedure: MB unroof; Procedure: MB CABG; Procedure: MBBG

Study type: Interventional

Funder types: Other

Identifiers

NCT06857838

XianInternationalMCH

Details and patient eligibility

About

Myocardial Bridge Bypass Graft surgery is introduced to relieve the unmedical symptoms of patients with long-segment or deep myocardial bridge, clinical outcomes will be collected to verify the effectiveness of the surgery.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with myocardialbridge requiring drug therapy or surgical intervention.

Exclusion criteria

• patients with myocardialbridge not requiring drug therapy or surgical intervention, or unwilling to be enrolled for any reason

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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500 participants in 3 patient groups

MyocardialBridge Bypass Graft

Experimental group

Description:

The patients with deep(depth\>2mm) and long-segement(length\>25mm) of myocardialbridge receiving myocardialbridge bypass graft surgery(MBBG)，fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. No atherosclerotic plaque or merely mild atherosclerotic stenosis is detected at the proximal or entry of the myocardialbridge confirmed by coronory artery angiography.

Treatment:

Procedure: MBBG

Myocardialbridge CABG

Active Comparator group

Description:

The patients with deep(depth\>2mm) and long-segement(length\>25mm) of myocardialbridge will be allocated to receive myocardialbridge bypass graft surgery(MBBG)，when fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. The moderate-to-severe atherosclertotic stenosis is detected at the proximal or entry of the myocardialbridge confirmed by coronory artery angiography.

Treatment:

Procedure: MB CABG

Myocardioalbridge Unroof

Active Comparator group

Description:

The patients with superficial type(depth\<2mm) and short-segement(length\<25mm) of myocardial bridge will be allocated to receive "unroof" surgery，when fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. No atherosclerotic plaque or merely mild atherosclerotic stenosis is detected at the proximal or entry end of the myocardialbridge confirmed by coronory artery angiography.

Treatment:

Procedure: MB unroof