Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry

Kansas City Heart Rhythm Research Foundation

Status: Not yet enrolling

Conditions: Premature Ventricular Contractions; Myocarditis; Ventricular Tachycardia (VT)

Study type: Observational

Funder types: Other

Identifiers

NCT05158751

KCHRF-MAVERIC REG-0009

Details and patient eligibility

About

To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.

Full description

Hypothesized that occult inflammation is clinically under-recognized in patients with symptomatic PVCs with and without Left ventricular (LV) dysfunction and can be a potential link between the 2 conditions. Aimed to evaluate the incidence of underlying inflammation using the Positron emission tomography (PET) scan in patients presenting with symptomatic PVCs enrolled retrospectively in the MAVERIC registry.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients > 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
• Non-sustained VT was defined as ≥3 more consecutive beats lasting <30 seconds

Exclusion criteria

• History of myocardial infarction,
• Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
• History of revascularization,
• Significant symptomatic atrial arrhythmias associated with LV dysfunction,
• Severe valvular disease,
• Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
• History of cardiac arrest,
• History of channelopathies or inherited arrhythmias.