Myocet, Docetaxel & Trastuzumab as 1st Line Treatment of Patients With HER-2/Neu Positive Metastatic Breast Cancer

Zeneus Pharma

Status and phase: Unknown; Phase 2

Conditions: Metastatic Breast Cancer

Treatments: Drug: Liposomal Doxorubicin (Myocet), Docetaxel and Trastuzumab

Study type: Interventional

Funder types: Industry

Identifiers

NCT00250874

Myocet 008 (L017)

Details and patient eligibility

About

To study the pharmacokinetic profile of the therapeutic schedule in order to demonstrate absence of negative interactions among the 3 drugs administered

Full description

1. To assess the maximum tolerated dose (MTD) of Myocet at different dosages in combination with Taxotere at the fixed dose of 35 mg/m2 on day 2 and 9 every 21 days and weekly Herceptin as first line therapy in patients affected by HER-2/neu positive metastatic breast cancer
2. To enhance the proportion of complete remission
3. To allow the feasibility of the combination of Herceptin with both Myocet and Taxotere without an enhanced risk of cardiotoxicity

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HER-2/neu overexpression assessed by FISH test or with immunohistochemical methods: Dako(the result must be 3+ with dakotest); if the immunohistochemical test results 2+ it is needed a positive FISH test
• Female < 70yrs
• Histologically or cytologically proven breast cancer.
• Metastatic or locally advanced breast cancer (clinical stage: III-IV)
• Adequate hematological, hepatic, renal and cardiac function, the latter confirmed by echocardiography with FEVS ≥50%
• Prior adjuvant chemotherapy if doxorubicin total dose ≤300 mg/m2, epirubicin total dose ≤450 mg/m2

Exclusion criteria

• History of cardiopathy
• Severe hepatic and renal diseases
• Brain metastases as the only parameter of disease
• Contraindication to the use of corticosteroids as premedication
• Acute infectious diseases
• Insulin-dependent diabetes
• History of other cancers except for adequately treated basal cell skin cancer or in situ carcinoma of the cervix
• Concurrent treatment with any other cancer therapy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)