Myotonia and Muscle Stiffness in NMD

LMU Klinikum

Status

Completed

Conditions

Neuromuscular Disorders

Treatments

Diagnostic Test: Six-minute walk test

Diagnostic Test: Hand-held Dynamometry of muscle strength

Device: MyotonPro

Diagnostic Test: Semiquantitative muscle ultrasound

Study type

Observational

Funder types

Other

Identifiers

NCT04411732

Version: 1 [01-JUL-2019]

Details and patient eligibility

About

The primary objective of this study is to assess stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia. The secondary objectives are (1) to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia; to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with non-myotonic neuromuscular disorders, (3) assess correlations between to compare result values for stiffness, muscle tone, relaxation periods and elasticity with clinical muscle function tests, measured by clinical evaluation (MRC-scale) and the 6-minute walk test; (4) assess correlations between subcutaneous fat and muscle thickness and echogenicity, measured by muscle ultrasound and result values for stiffness, muscle tone, relaxation periods and elasticity.

Enrollment

133 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

For Patients:

≥18 years of age
Confirmed neuromuscular disease
written consent
able and willing to perform study prodcedures

For healthy volunteers:

age ≥18 years of age
written informed consent
no clinical sign for neuromuscular disorders

Exclusion criteria

Severe comorbidities
Patient is participating in another clinical study using investigational treatment
Patient cannot perform required muscle function tests
the patient, in the opinion of the investigator, is unable to adhere to the requirements of the study