Myotonic Dystrophy Type 1 and Resistance Exercise (STYRK DM1)

Norwegian School of Sport Sciences

Status: Completed

Conditions: Myotonic Dystrophy 1

Treatments: Other: Moderate-Heavy Resistance Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05036447

STYRK DM1

Details and patient eligibility

About

The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1. There is still doubt about if these patients could benefit from resistance exercise, or if this mode of exercise is detrimental to their mobility and health. We aim to monitor the subjects during the recovery phase and investigate recovery in several ways.

Full description

Myotonic dystrophy type 1 (DM1) is an autosomal, dominantly inherited, muscular disease and the most common muscular dystrophy amongst adults. The disease is characterized by progressive myopathy and myotonia, first evident in the distal parts of the body: calves and forearms, further progressing towards proximal parts. A recent review by Voet and co-workers (2013) concludes that exercise is safe for DM1-patients, and based on our current knowledge, DM1-patients should be able to gain positive adaptations from exercise. However, the physiological outcomes of an exercise stimulus are not well studied in this population and because of alterations in important Ca2+ handling systems the recovery processes might be significantly different from healthy muscles.

The aim of this study is to investigate the acute responses to moderate-heavy resistance exercise in DM1-patients. We aim to establish a timeline for recovery of muscle strength, measured as maximal voluntary contraction. In line with this, we want to investigate if any muscular damage has occurred with both direct and indirect measures, and possible mechanisms leading to muscle damage, i.e. impaired Ca2+ handling.

Enrollment: 21 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Confirmed Myotonic Dystrophy type 1-diagnosis

Exclusion criteria

• Non-ambulatory
• Injuries to muscle-skeletal-system that prevents resistance exercise
• Severe affection of the cardiovascular system
• Cognitive affection
• Lives more than one hour from test site

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

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21 participants in 4 patient groups

DM1-Ex

Experimental group

Description:

Moderate-heavy resistance exercise of one leg in DM1-patients

Treatment:

Other: Moderate-Heavy Resistance Exercise

DM1-Rest

No Intervention group

Description:

Control leg (i.e. no exercise) in DM1-patients

Ctrl-Ex

Experimental group

Description:

Moderate-heavy resistance exercise of one leg in healthy participants

Treatment:

Other: Moderate-Heavy Resistance Exercise

Ctrl-Rest

No Intervention group

Description:

Control leg (i.e. no exercise) in healthy participants