N-acetyl-cysteine and Carbohydrate Metabolism Disorder in Obese Women

Poznan University of Life Sciences

Status: Unknown

Conditions: Carbohydrate Metabolism Disorder; Insulin Resistance; Obesity

Treatments: Dietary Supplement: NAC group; Dietary Supplement: Control group

Study type: Interventional

Funder types: Other

Identifiers

NCT03902327

PoznanULS

Details and patient eligibility

About

The effect of N-acetylcysteine supplementation on carbohydrate metabolism disorder and homocysteine concentrations in obese women will be analysed.

Enrollment: 30 estimated patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• women diagnosed with carbohydrate metabolism disorder,
• obesity (BMI >29,9 kg/m2)
• patients not participating in other similar research programs at the same time,
• written agreement to take part in the research.

Exclusion criteria

• the use of medicament that may affect on carbohydrate metabolism within 4 weeks,
• failure to comply with dietary recommendations established during the nutritional intervention,
• pregnancy and breast feeding.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

30 participants in 2 patient groups

NAC group

Experimental group

Description:

NAC for 12 weeks, 1.6 mg/day, 4x400 mg; a diet based on general recommendations for people with carbohydrate metabolism disorder

Treatment:

Dietary Supplement: NAC group

Control group

Active Comparator group

Description:

Placebo for 12 weeks and a diet based on general recommendations for people with carbohydrate metabolism disorder

Treatment:

Dietary Supplement: Control group