N- Acetylcysteine in Airway Clearance in Broncheictasis

Assiut University

Status: Not yet enrolling

Conditions: Broncheictasis

Treatments: Drug: N Acetyle cysteine given by IV injection; Drug: Nebulized N Acetyle cysteine

Study type: Interventional

Funder types: Other

Identifiers

NCT07293884

NAcetylcysteine broncheictasis

Details and patient eligibility

About

It has been deduced that reducing the production of mucus or improving the clearance of sputum in the airway is the key to enhance the therapeutic efficacy for bronchiectasis . Mucoactive drugs are commonly used to clear the airway in mucus hypersecretion diseases. Currently, investigators have found that N-acetylcysteine (NAC), an effective mucolytic agent, not only reduces the viscosity and elasticity of sputum, but it also has anti-inflammatory and antioxidant activity.

Additionally, the Spanish guidelines on the treatment of bronchiectasis indicate that the use of N-acetylcysteine should be considered for patients with bronchiectasis and COPD. Therefore, as a classic mucolytic agent with antioxidant and anti-inflammatory properties, N-acetylcysteine can be effective in the treatment of bronchiectasis

Enrollment: 70 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Subjects aged above 18 years old; with a diagnosis of bronchiectasis who are admitted to chest department due to acute exacerbation

Exclusion criteria

• current smokers, a known allergy to N-acetylcysteine; pregnancy or lactation (for women); primary diagnosis of COPD or asthma

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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70 participants in 2 patient groups

IV N Acetyle cysteine

Active Comparator group

Description:

Intervention: N Acetyle cysteine given by IV injection

Treatment:

Drug: N Acetyle cysteine given by IV injection

Nebulized N Acetyle cysteine

Active Comparator group

Description:

Intervention: Nebulized N Acetyle cysteine

Treatment:

Drug: Nebulized N Acetyle cysteine