N2004-03: Intravenous Fenretinide in Treating Young Patients With Recurrent or Resistant Neuroblastoma (IV Fenretinide)

Nant Operations Center

Status and phase

Completed

Phase 1

Conditions

Neuroblastoma

Treatments

Other: pharmacological study

Other: high performance liquid chromatography

Drug: fenretinide

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00646230

CDR0000584267

N2004-03 (Other Identifier)

P01CA081403 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

RATIONALE: Drugs used in chemotherapy, such as fenretinide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.

PURPOSE: This phase I trial is studying the side effects and best dose of intravenous fenretinide in treating young patients with recurrent or resistant neuroblastoma.

Full description

OBJECTIVES:

Primary

To determine the maximum tolerated dose of fenretinide when given as a continuous intravenous infusion in young patients with recurrent and/or resistant neuroblastoma.
To define the toxicities of this drug in these patients.
To determine the plasma pharmacokinetics of this drug in these patients.

Secondary

To determine the response rate in patients treated with this drug.
To determine the bioavailability of fenretinide in normal peripheral blood mononuclear cells as a surrogate marker for drug bioavailability to tumor tissue.

OUTLINE: This is a multicenter study.

Patients receive fenretinide IV continuously over 120 hours on days 0-4. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.

Blood samples are collected periodically for pharmacokinetic analysis by high performance liquid chromatography.

After completion of study treatment, patients are followed periodically.

Enrollment

17 patients

Sex

All

Ages

Under 30 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Diagnosis of neuroblastoma either by histological confirmation and/or demonstration of tumor cells in the bone marrow with increased urinary catecholamines
- Differentiating ganglioneuroblastoma allowed
  - No histological evidence only of ganglioneuroma by tumor biopsy or bone marrow biopsy
High-risk disease meeting at least one of the following criteria:
- Recurrent/progressive disease at any time
- Refractory disease (i.e., less than a partial response to front-line therapy that included ≥ 4 courses of chemotherapy)
- Persistent disease after at least a partial response to front-line therapy (i.e., still has residual disease by MIBG, CT/MRI, or bone marrow biopsy)
  - Biopsy of at least one residual site demonstrating viable neuroblastoma required (tumor by bone marrow morphology is considered adequate documentation of disease)
Measurable disease meeting at least one of the following criteria:
- Measurable tumor on MRI or CT scan, defined as at least one unidimensionally measurable lesion ≥ 20 mm by conventional techniques or ≥ 10 mm by spiral CT scan
  - For patients with persistent disease, a biopsy* of bone marrow or bone or soft tissue site must have demonstrated viable neuroblastoma
- MIBG scan with positive uptake at a minimum of one site
  - For patients with persistent disease, a biopsy* of a MIBG positive site must have demonstrated viable neuroblastoma
- Bone marrow with tumor cells seen on routine morphology (not by NSE staining only) of bilateral aspirate and/or biopsy of one bone marrow sample NOTE: *If the lesion was irradiated, the biopsy must have been done at least 4 weeks after completion of radiotherapy
No CNS parenchymal or meningeal-based lesions
- Skull-based tumor lesions with or without intracranial extension are allowed provided there are no neurologic signs or symptoms or hydrocephalus related to the lesion
- Patients with a history of complete surgical resection of CNS lesions are eligible provided there is no evidence of CNS lesions by MRI or CT scan at study entry
- Patients with a history of CNS lesions must be off corticosteroid therapy for CNS lesions for ≥ 4 weeks

PATIENT CHARACTERISTICS:

Performance status 0-2
Life expectancy ≥ 2 months
ANC ≥ 500/mm³
Platelet count ≥ 50,000/mm³ (transfusion independent)
Hemoglobin ≥ 8.0 g/dL (transfusion independent)
Serum creatinine ≤ 1.5 times normal for age
Total bilirubin ≤ 1.5 times normal for age
ALT and AST ≤ 3 times normal for age
Serum triglycerides < 300 mg/dL
Serum calcium < 11.6 mg/dL
Lipase normal for age
PT/PTT ≤ 1.5 times upper limit of normal for age (without fresh frozen plasma support; vitamin K allowed)
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception prior to, during, and for 2 months after completion of study treatment
LVEF ≥ 55% by ECHO or MUGA scan OR fractional shortening ≥ 27% by ECHO
No EKG abnormality
No dyspnea at rest or requirement for oxygen
No hematuria and/or proteinuria > 1+ on urinalysis
No known history of allergy to egg products
No known history of allergy to soy bean oil
No skin toxicity > grade 1 per CTCAE v3
Seizure disorder allowed if seizures are controlled on anticonvulsants and the anticonvulsant(s) is not contraindicated
Known genetic, metabolic, or psychiatric conditions, or other ongoing serious medical issues must be approved by the study chair prior to study registration

PRIOR CONCURRENT THERAPY:

Recovered from all prior chemotherapy, immunotherapy, or radiotherapy
More than 3 weeks since prior myelosuppressive chemotherapy (4 weeks for nitrosoureas) and/or biologic therapy without stem cell support
More than 7 days since prior hematopoietic growth factors
No prior radiotherapy to the only site of measurable disease unless there has been subsequent disease progression at that site or a biopsy of that site showed viable neuroblastoma ≥ 4 weeks after completion of radiotherapy
Prior CNS irradiation allowed
At least 2 weeks since prior small field (focal) radiotherapy
At least 6 weeks since prior large field radiotherapy (i.e., total-body irradiation, craniospinal radiotherapy, whole abdominal or total lung radiotherapy, or radiotherapy to > 50% of marrow space)
At least 56 days since prior myeloablative autologous stem cell transplantation
At least 4 weeks since prior myelosuppressive therapy with stem cell support
At least 6 weeks since prior MIBG therapy
Prior oral fenretinide therapy allowed
At least 3 weeks since prior retinoid therapies
No prior organ transplantation
No prior myeloablative allogeneic stem cell transplantation unless stem cells were from an identical twin sibling
No concurrent systemic corticosteroids, including corticosteroids for emesis control
- Concurrent inhaled corticosteroids for asthma control or steroids for metabolic deficiency states allowed
Concurrent palliative radiotherapy allowed provided the irradiated sites will not be used to measure response
No concurrent parenteral intralipids
No other concurrent chemotherapy or immunomodulating agents
No concurrent drugs suspected of causing pseudotumor cerebri, including tetracycline, nalidixic acid, nitrofurantoin, phenytoin, sulfonamides, lithium, or amiodarone
No concurrent vitamin A, C, or E supplements (except as part of routine total parenteral nutrition [TPN] supplements or as part of a single daily standard dose of oral multivitamin supplement)
No concurrent medications that may potentially act as modulators of intracellular ceramide levels or ceramide cytotoxicity, sphingolipid transport, or p-glycoprotein (MDR1) or MDR1 drug/lipid transporters, including cyclosporine or analogue, verapamil, tamoxifen or analogue, ketoconazole, chlorpromazine, mifepristone (RU486), indomethacin, or sulfinpyrazone
No other concurrent anticancer agents
No concurrent herbal supplements or other alternative therapy medications
No concurrent anti-arrhythmia or inotropic cardiac medications