NAD Supplementation Study (NADS)

Maastricht University

Status

Terminated

Conditions

Aging

Mitochondrial Function

Treatments

Dietary Supplement: NAD-precursors

Dietary Supplement: Control

Study type

Interventional

Funder types

Other

Identifiers

NCT03310034

NL61204.068.17

Details and patient eligibility

About

This research project aims to determine whether supplementing with a mixture of the NAD+-precursors NA, NAM, and tryptophan can stimulate skeletal muscle mitochondrial function in physically compromised, elderly humans. Outcomes are related to mitochondrial function, energy metabolism, and physical function will be investigated.

Enrollment

14 patients

Sex

All

Ages

65 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Males and females
Age ≥ 65 ≤ 75 years;
BMI ≥ 20 kg/m2 ≤ 30 kg/m2;
Normal physical activity levels: maximum of 1 hour per week engagement in a structured exercise session;
SPPB score 4-9 and (pre-)frail;
Subject should be in sufficient health to participate in the experiments, to be judged by the responsible physician based on the subject's medical history.

Exclusion criteria

Not meeting all inclusion criteria;
Smoking;
Excessive alcohol use and/or drug abuse;
Subjects with diabetes mellitus type 2;
Significant food allergies or intolerances concerning the study products;
Participation in another biomedical study within 1 month before the first study visit, possibly interfering with the study results;
Medication use known to hamper subject's safety during the study procedures;
Subjects who use selective serotonin re-uptake inhibitors (SSRI), or selective norepinephrin re-uptake inhibitors (SNRI), or monoamino oxidase inhibitors (MAO-inhibitors), or clomipramine, or St. John's wort (Hypericum perforatum);
Subjects with contra-indications for MRI;
Subjects who do not want to be informed about unexpected medical findings;
Subjects who do not want that their treating physician to be informed;
Co-morbidities to which the intervention or program the may pose as a complicating factor;
Inability to participate and/or complete the required measurements.