Naloxone to TReatment Entry in the Emergency Setting (N-TREE)

Anders C Håkansson

Status: Withdrawn

Conditions: Opioid Intoxication; Substance Use Disorders; Opioid Dependence

Treatments: Behavioral: Control; Behavioral: Active treatment referral of opioid overdose survivors to long-term treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT03368794

N-TREE

Details and patient eligibility

About

The study tests a structured referral process for opioid overdose survivors, from pre-hospital emergency care to long-term treatment of the individual's substance use-related disorder.

Full description

Randomized controlled trial. Subjects are included if they are being treated by an ambulance in the Malmö uptake are for an opioid overdose requiring naloxone antidote administration, and if they sign informed written consent to the study. Subjects are randomized by ambulance staff to either an active intervention, or a control condition:

Intervention: A telephone alert signal is sent from ambulance staff after successful naloxone reversal of an opioid overdose, leading to an active outreach effort from the staff of the addiction research facility, where staff locate the individual and offer her/him formal inclusion in the study.

Control: No telephone alert signal is sent, and the active outreach procedure is not carried out. Ambulance staff hand over written information to the individual about how she/he can apply actively for treatment.

Primary outcome is entry into formal assessment and treatment of the substance use disorder.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• survivor of opioid overdose requiring antidote naloxone administration by ambulance staff, and provision of written informed consent

Exclusion criteria

• patients unable to understand study information and to provide informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Intervention

Experimental group

Description:

Telephone alert signal from ambulance staff to out-patient substance use disorder treatment facility, for active outreach aiming to locate and include the patient in long-term evidence-based treatment for the substance use disorder.

Treatment:

Behavioral: Active treatment referral of opioid overdose survivors to long-term treatment

Control

Active Comparator group

Description:

Information-only. Ambulance staff hand over written information to the individual about how to seek treatment for the substance use disorder.

Treatment:

Behavioral: Control