Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects

Weam Ahmed Elbattawy

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Procedure: n-HA bone graft; Procedure: open flap debridement

Study type: Interventional

Funder types: Other

Identifiers

NCT04643288

nano version 1

Details and patient eligibility

About

The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis. Subjects were recruited from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University. This clinical trial was meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with open flap debridement versus open flap debridement alone in the treatment of periodontal intrabony defects.

Full description

periodontal intrabony defects in patients with moderate or advanced chronic periodontitis were treated with open flap debridement only in the control group while open flap debridement and Nanocrystalline Hydroxyapatite bone graft substitute was performed for the intervention group. probing pocket depth, clinical attachment level, gingival index, plaque index, gingival recession and bone defect area were assessed at baseline and six months post surgically to evaluate the possible improvement in the clinical and radiographic outcomes.

Enrollment: 20 patients

Sex: All

Ages: 35 to 56 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• systemically healthy patients
• diagnosed with moderate to advanced chronic periodontitis
• periodontal defects with at least one site with probing pocket depth (PPD) ≥ 5mm, clinical attachment loss (CAL) ≥ 4mm and two or three-walled intra-bony defects ≥ 3mm
• evidence of intrabony defects using periapical radiographs

Exclusion criteria

• teeth with suprabony defects or 1-wall intrabony defects
• pregnant or lactating women
• patients taking any medication 3 months prior to the study
• patients receiving any periodontal treatment 6 months prior to study initiation
• former or current smokers.

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

OFD control group

Experimental group

Description:

open flap debridement for periodontal intrabony defects

Treatment:

Procedure: open flap debridement

n-HA bone graft intervention group

Experimental group

Description:

Nanocrystalline Hydroxyapatite (n-HA) bone graft substitute was added to periodontal intrabony defects

Treatment:

Procedure: open flap debridement

Procedure: n-HA bone graft