Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

M.D. Anderson Cancer Center

Status: Begins enrollment in 2 months

Conditions: Pulsed Field Ablation; Thyroid Nodules

Treatments: Other: Questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT07226804

NCI-2025-08362 (Other Identifier)

2025-0483

Details and patient eligibility

About

To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.

Full description

Primary Objectives

• To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care

Secondary Objectives

• To determine changes in health-related quality of life changes following ultrasound-guided nsPFA
• To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA.
• To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Eligibility Criteria

• Scheduled to undergo ultrasound guided nsPFA as standard of care

• Age 18 to 80 years.

• Capable of providing independent consent.

• Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:

  • Benign FNA X 2 or
  • Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
  • Benign FNA X 1 and radiographic/laboratory evidence of functional nature

• Nodule measuring >2cm in greatest dimension

• Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)

• No abnormal cervical lymph nodes during screening visit .

Exclusion Criteria

• Age <18
• Patients considered unsuitable for nsPFA by the treating physician