Narrow Band Imaging (NBI) Against Lugol for Squamous Esophageal Cancer

The Chinese University of Hong Kong

Status: Completed

Conditions: Superficial Esophageal Neoplasia

Study type: Observational

Funder types: Other

Identifiers

NCT02002559

2006.077

Details and patient eligibility

About

This study aimed to compare Narrow Band Imaging (NBI) against Lugol chromoendoscopy for diagnosis of early esophageal cancers among high risk patients.

Full description

The investigators recruited consecutive patients with head and neck cancers, history of squamous esophageal cancers treated by chemoradiotherapy or endoscopic resection. Endoscopic surveillance first started with NBI for detection and characterization of early esophageal cancers through observation of abnormal intrapapillary capillary loops (IPCL). Superficial esophageal neoplasia were diagnosed by IPCL Type IV, V1,V2 and Vn. Lugol chromoendoscopy would be performed subsequently and suspicious neoplasia were classified as understain or unstain lesions. The diagnostic accuracy, sensitivity and specificity of NBI were compared to Lugol chromoendoscopy with histology serving as a gold standard.

Enrollment: 180 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with Head and Neck Cancer
2. Patients with esophageal cancer treated by chemoradiotherapy and in remission for 2 years
3. Patients with esophageal cancer treated by endoscopic resection
4. Age 18 to 80

Exclusion criteria

1. Allergy to Lugol iodine
2. Pregnancy
3. Previous esophagectomy

Trial design

180 participants in 2 patient groups

NBI Magnify Endoscopy

Description:

Detection of esphageal neoplasia through recognition of brownish discolored area via NBI and characterize the lesion using IPCL upon magnifying endoscopy

Lugol Chromoendoscopy

Description:

Detection of esophageal neoplasia through recognition of discolored area