Narrow QRS Ischemic Patients Treated With Cardiac Resynchronization Therapy (NARROW CRT) (NARROW-CRT)

Ospedale Santa Maria di Loreto Mare

Status: Completed

Conditions: Heart Failure, Systolic

Treatments: Procedure: cardiac resynchronization therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01577446

LM-002

Details and patient eligibility

About

Current recommendations require a QRS duration of ≥120ms as a condition for prescribing cardiac resynchronization therapy (CRT). This study was designed to test the hypothesis that patients with heart failure of ischemic origin, current indications for defibrillator implantation and QRS <120ms may benefit from CRT in the presence of marked mechanical dyssynchrony.

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• NHYA class II-III heart failure
• ischemic cardiomyopathy
• ejection fraction of 35% or less
• QRS interval of 120ms or less
• evidence of mechanical dyssynchrony as measured on echocardiography

Exclusion criteria

• conventional indication for cardiac pacing
• persistent atrial fibrillation
• life expectancy lower than 1 year

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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120 participants in 2 patient groups

CRT

Experimental group

Description:

The CRT group undergoes implantation of a CRT defibrillator

Treatment:

Procedure: cardiac resynchronization therapy

no-CRT

No Intervention group

Description:

The no-CRT group receives a dual-chamber defibrillator