Nasal Airflow to Modulate Dyspnea in Tracheostomized Patients (MODUS)

Assistance Publique - Hôpitaux de Paris

Status: Not yet enrolling

Conditions: Ventilated Patients

Treatments: Procedure: propeller fan (FAN); Procedure: Nasal air puffs; Procedure: Installation of high flow humidified air cannula; Procedure: Baseline

Study type: Interventional

Funder types: Other

Identifiers

NCT07308171

APHP251423

Details and patient eligibility

About

The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.

Full description

Nasal stimulation is generated by breathing, which enables olfaction and helps to rhythm brain activity. The loss of nasal stimulation in tracheotomized patients who are dependent on mechanical ventilation may negatively affect respiratory drive and contribute to dyspnea. Restoring nasal airflow therefore emerges as an attractive non-pharmacological approach to treat dyspnea in patients undergoing mechanical ventilation weaning.

The hypothesis of the present study is that restoring nasal stimulation alleviates dyspnea and improves respiratory drive. The aim of this study is to compare three non-pharmacological approaches designed to restore nasal stimulation (continuous nasal airflow, nasal sprays, and facial airflow) in tracheotomized patients dependent on mechanical ventilation.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 18 years
2. Tracheostomy and mechanical ventilation
3. Dyspnea ≥3
4. Consent to participate
5. Affiliation to health insurance

Exclusion criteria

1. Agitation, delirium
2. Continuous use of sedatives
3. Patients under law protection
4. Inmates
5. Patients without health insurance
6. Breastfeeding and pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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24 participants in 1 patient group

Patients ventilated

Experimental group

Description:

Baseline ventilator settings under pressure support

Treatment:

Procedure: Baseline

Procedure: Installation of high flow humidified air cannula

Procedure: Nasal air puffs

Procedure: propeller fan (FAN)