Nasal Carrying by Staphylococcus Aureus ST398 Strains in Community and Hospital Settings (CONASA 398)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Staphylococcus Aureus Nasal Carriage

Treatments: Procedure: Nasal swab

Study type: Observational

Funder types: Other

Identifiers

NCT03869255

API/2018/96

Details and patient eligibility

About

The aim of this study was to compare the prevalence of nasal carrying of SA ST398 strains in community and hospital settings, identify the factors associated with colonization of SA ST398, determine the distribution of imported and acquired cases among SA ST398 hospital cases and characterize the genetic structure of the ST398 SA population involved in colonization.

Full description

Staphylococcus aureus (SA) is a ubiquitous bacterium, part of the human commensal flora. The mucosa of the anterior nasal cavities represents the preferred site of colonization of SA. The SA ST398 clone, belonging to CC 398, was initially described as a zoonotic agent initially identified in France and the Netherlands. In fact, ST398 strains are separated into two distinct populations: a methicillin-resistant SA population (SAMR) with notion of contact with animals and a more virulent methicillin-sensitive SA population (SAMS) than its counterpart, isolated from serious human infections and without notion of exposure to farm animals. Recently, we have shown that, in SA bacteremia, all strains of SA ST398 are sensitive to methicillin and that the prevalence of ST398 among all SAMS responsible for bacteremia at Besançon University Hospital increased between 2009 and 2014, increased from 4 to 15%. However, we were unable to study nasal colonization to support the mode of acquisition of SA ST398 (community vs. healthcare acquisition).

Enrollment: 2,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

For community patients :

Inclusion Criteria:

• the selection criteria for blood donation
• age ≥ 18 years old
• No refusal of the person

Exclusion Criteria:

• None

For hospitalized patients :

Inclusion Criteria:

• age ≥ 18 years old
• hospitalization in one of the services participating in the study
• no refusal of the person

Exclusion Criteria:

• None

Trial design

2,000 participants in 2 patient groups

Hospitalized patients

Description:

Within 48 hours of admission to participating departments, all patiens will be included. A nasal swab will be performed within the first 48 hours and on the 7th day.

Treatment:

Procedure: Nasal swab

Community patients

Description:

People coming to donate blood in "Etablissement Français du Sang" will be included and a nasal swab will be performed

Treatment:

Procedure: Nasal swab