Nasal EPAP for Stroke Patients With Sleep Apnea: a Pilot Trial.

University of Michigan

Status

Completed

Conditions

Ischemic Stroke

Obstructive Sleep Apnea

Treatments

Device: EPAP

Study type

Interventional

Funder types

Other

Identifiers

NCT01703663

U037625

Details and patient eligibility

About

Specific aim: To test the effects of nasal expiratory positive airway pressure (EPAP) therapy on sleep apnea severity among patients with recent ischemic stroke.

Hypothesis 1: Ischemic stroke patients with sleep apnea will have less severe sleep apnea, as measured by the apnea-hypopnea index (AHI), with nasal EPAP therapy compared with a control night.

Hypothesis 2: Ischemic stroke patients will have higher mean levels of oxygen saturation with nasal EPAP therapy compared with a control night.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

adults with an ischemic stroke (including TIA with infarction) within the prior 14 days

Exclusion criteria

Current use of any transnasal tube (eg dobhoff tube)
Current use of CPAP, mechanical ventilation, or supplemental oxygen
Known severe breathing disorders including hypercapnic respiratory failure, respiratory muscle weakness, bullous lung disease, bypassed upper airway, pneumothorax, pneumomediastinum
Severe heart disease (including severe heart failure)
Pathologically low blood pressure
An acute upper respiratory (including nasal, sinus or middle ear) inflammation or infection, or perforation of the ear drum
Sores, abrasions, or skin or mucosal irritation on or around the nose.
Known pregnancy
Inability to provide informed consent
Use of alpha blockers or short acting nitrates
Permanent pacemaker
Sustained non-sinus cardiac arrhythmia