Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

National Institutes of Health (NIH)

Status: Completed

Conditions: Rhinitis, Allergic, Nonseasonal

Treatments: Procedure: Nasal irritation thresholds and irritant provocation

Study type: Interventional

Funder types: NIH

Identifiers

NCT00041821

10424-CP-001

Details and patient eligibility

About

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Sex: All

Ages: 18 to 69 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Non-smokers
• 18-69 years of age
• With or without allergic rhinitis (hay fever)
• In good general health and with no prior history of asthma