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Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation

L

Liita Care

Status

Unknown

Conditions

Obstructive Airway Diseases

Treatments

Device: Inhalation from a salt particle inhaler with or without content

Study type

Interventional

Funder types

Industry

Identifiers

Details and patient eligibility

About

Investigating nasal muco-ciliary clearance by scintigraphy

Full description

The velocity and the retention of the nasal muco-ciliary clearance is going to be investigated with a salt particle inhaler and a placebo by the method nasal scintigraphy.

The hypotheses is that nasal inhalation of salt particles enhance the nasal mucociliary clearance.

Enrollment

31 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • COPD patients (all severities in chronic, stable condition)
  • Asthma patients (in stable condition without acute asthma symptoms)
  • Healthy subjects, incl. smokers (no chronic nasal, upper or lower respiratory diseases)

Exclusion criteria

  • Age under 18 years
  • Upper respiratory tract infection / cold within the last 3 weeks and at least 3 weeks must pass from the person has become well to the examination
  • Allergic / non-allergic rhinitis (hay fever)
  • Chronic sinusitis
  • Acute respiratory tract infection in antibiotic therapy
  • Applied salt inhalation within the past month
  • Pregnant or breastfeeding women
  • Nuclear medical examination within the past month
  • Cannot taste saccharin

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Double Blind

31 participants in 2 patient groups, including a placebo group

Salt particle inhaler with content
Active Comparator group
Description:
Participants inhaling from a salt particle inhaler with content
Treatment:
Device: Inhalation from a salt particle inhaler with or without content
Salt particle inhaler without content
Placebo Comparator group
Description:
Participants inhaling from a salt particle inhaler without content
Treatment:
Device: Inhalation from a salt particle inhaler with or without content

Trial contacts and locations

1

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Central trial contact

Zainab Saraj, Cand.Pharm.

Data sourced from clinicaltrials.gov

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