Nasal Muco-ciliary Clearance Study With and Without Salt Inhalation

Liita Care

Status: Unknown

Conditions: Obstructive Airway Diseases

Treatments: Device: Inhalation from a salt particle inhaler with or without content

Study type: Interventional

Funder types: Industry

Identifiers

NCT04189016

LC.002

Details and patient eligibility

About

Investigating nasal muco-ciliary clearance by scintigraphy

Full description

The velocity and the retention of the nasal muco-ciliary clearance is going to be investigated with a salt particle inhaler and a placebo by the method nasal scintigraphy.

The hypotheses is that nasal inhalation of salt particles enhance the nasal mucociliary clearance.

Enrollment: 31 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• COPD patients (all severities in chronic, stable condition)
• Asthma patients (in stable condition without acute asthma symptoms)
• Healthy subjects, incl. smokers (no chronic nasal, upper or lower respiratory diseases)

Exclusion criteria

• Age under 18 years
• Upper respiratory tract infection / cold within the last 3 weeks and at least 3 weeks must pass from the person has become well to the examination
• Allergic / non-allergic rhinitis (hay fever)
• Chronic sinusitis
• Acute respiratory tract infection in antibiotic therapy
• Applied salt inhalation within the past month
• Pregnant or breastfeeding women
• Nuclear medical examination within the past month
• Cannot taste saccharin

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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31 participants in 2 patient groups, including a placebo group

Salt particle inhaler with content

Active Comparator group

Description:

Participants inhaling from a salt particle inhaler with content

Treatment:

Device: Inhalation from a salt particle inhaler with or without content

Salt particle inhaler without content

Placebo Comparator group

Description:

Participants inhaling from a salt particle inhaler without content

Treatment:

Device: Inhalation from a salt particle inhaler with or without content