Nasal Provocation Test With Lysine-Acetylsalicylate (ASA) in Patients With Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Hypersensitivity

Chulalongkorn University

Status: Completed

Conditions: Aspirin Hypersensitivity; NSAIDs Hypersensitivity

Treatments: Procedure: Lysine-ASA Nasal ProvocationTest

Study type: Interventional

Funder types: Other

Identifiers

NCT00815126

Chula-ARC 002/08

Details and patient eligibility

About

This study aims to compare the efficacy of nasal provocation test with Lysine-Acetylsalicylate in patients with history of NSAIDs hypersensitivity between mucocutaneous symptoms and respiratory symptoms and laboratory outcomes.

Enrollment: 34 patients

Sex: All

Ages: 15 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with history of ASA/NSAIDs hypersensitivity with mucocutaneous symptoms and/or respiratory symptoms

Exclusion criteria

• Patients who cannot discontinue drugs before the test as follow

  • Nasal corticosteroids/Oral corticosteroids/Leukotriene modifiers for 1 week
  • Short-acting antihistamines for 3 days
  • Nasal a-mimetics/Oral a-mimetics/Local cromones for 24 hours

• Contraindicated for nasal provocation test: pregnant, exacerbation of allergic rhinitis/asthma, having upper respiratory tract infection within 2 weeks prior to the test, having nose surgery within 8 weeks prior to the test, having severe systemic disease(s)

• Having factors interfere nasal provocation test with Lysine-ASA such as massive nasal polyp, nasal septal perforation, total nasal obstruction at least 1 nostril

Trial design

34 participants in 3 patient groups

Mucocutaneous symptoms from NSAIDs

Active Comparator group

Treatment:

Procedure: Lysine-ASA Nasal ProvocationTest

Respiratory symptoms from NSAIDs

Active Comparator group

Treatment:

Procedure: Lysine-ASA Nasal ProvocationTest

NSAIDs tolerant individuals

Active Comparator group

Treatment:

Procedure: Lysine-ASA Nasal ProvocationTest