Nasal Provocation Testing in Occupational Rhinitis (NPT)

Haukeland University Hospital

Status: Completed

Conditions: Allergic Rhinitis (Disorder)

Treatments: Biological: Storage mite allergen extracts

Study type: Interventional

Funder types: Other

Identifiers

NCT01436851

2009/265

Details and patient eligibility

About

In a previous study the investigators found that many bakery workers were sensitized to storage mites, and many had rhinitis symptoms. The role of storage mites as an occupational allergen with clinical relevance has been questioned, and the investigators wanted to investigate whether a nasal provocation with a storage mite extract would trigger symptoms and objective signs of rhinitis in bakery workers and a control group.

Full description

The investigations include allergy testing with skin prick testing, and measuring of specific Immunoglobulin E (IgE) in sera, answering a questionnaire, and symptom scoring before and after provocations. The participants will be investigated one day with a placebo, and another day with the allergen extract of either Acarus Siro or Lepidoglyphus Destructor. As a measurement of nasal patency we use the nasal peak inspiratory flow meter, but also clinical scoring of nasal secretion and blockage. Indices of inflammation (ECP and alfa-Macroglobulin) will be monitored in nasal lavage.

Enrollment: 17 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• bakery workers
• > 18 years
• sensitized to a storage mite (A.Siro or L. Destructor)

Exclusion criteria

• pregnant or breast-feeding
• infection in upper or lower airways the last month
• nasal polyposis

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

Storage mite and placebo nasal challenge

Experimental group

Description:

Provocation in the nose with an allergen extract of a storage mite (A. Siro or L. Destructor) and with placebo allergen extract (physiologic salt water)

Treatment:

Biological: Storage mite allergen extracts